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📊 Side Effect Matrix of Atypical Antipsychotics
- Aufrufe Aufrufe: 59
- Letzte Aktualisierung Letzte Aktualisierung:
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Inhalt
Visual Side Effect Matrix of Atypical Antipsychotics
Rough orientation values, will be revised in more detail
Side Effect 
Lurasidone Brexpiprazole Cariprazine
Ziprasidone Aripiprazole
Amisulpride Paliperidone Risperidone
Quetiapine Olanzapine Clozapine
Weight Gain¹ +0.3 kg +0.6 kg +0.4 kg +0.5 kg +0.75 kg +2.5 kg +1.8 kg +2.1 kg +2.9 kg +4.1 kg +4.5 kg
Sedation mild mild mild mild mild moderate moderate moderate strong very strong very strong
Prolactin↑ low low minimal minimal none high high high moderate moderate low
QTc Prolongation low low low high low low high high low low low
Akathisia high moderate high high high moderate high high moderate moderate none Parkinsonism moderate moderate moderate moderate moderate high moderate high moderate moderate moderate
Tardive Dyskinesia moderate moderate moderate moderate moderate high moderate high moderate moderate high
Diabetes Risk none low none none none moderate moderate moderate moderate high high
Orthostatic Dysreg. moderate moderate moderate moderate moderate moderate moderate moderate high high high
Hypertension low low low none low moderate high high low moderate moderate
Constipation low low low low low moderate moderate moderate moderate high very high
Salivation none none none none none moderate moderate moderate none moderate very high
Legend- = Low / Well tolerated
- = Mild / Noticeable
- = Moderate / Clinically relevant
- = High / Frequently problematic
- ¹ Weight gain over ~6 weeks (median), based on Pillinger et al. (2019)
Based on median values over ~6 weeks; clinical experience and S3 guidelines
Side Effect Matrix of Atypical Antipsychotics
Drug Weight Gain¹ Sedation Prolactin↑ QTc↑ Akathisia Parkinsonism Tardive Dyskinesia Diabetes Risk Orthostatic Dysreg. Hypertension Constipation Salivation Lurasidone +0.3 kg + + + ++ + + 0 + 0/+ 0/+ 0 Brexpiprazole +0.6 kg + + + + + + 0/+ + 0/+ 0/+ 0 Cariprazine +0.4 kg + 0/+ + ++ + + 0 + 0/+ 0/+ 0 Ziprasidone +0.5 kg + 0/+ ++ ++ + + 0 + 0 0/+ 0 Aripiprazole +0.75 kg + 0 + ++ + 0 + 0/+ 0/+ 0/+ 0 Amisulpride +2.5 kg ++ +++ + + ++ ++ + + + + + Paliperidone +1.8 kg ++ +++ ++ ++ + + + + ++ + + Risperidone +2.1 kg ++ +++ ++ ++ ++ ++ + ++ + + + Quetiapine +2.9 kg ++ + + + + + + 0/+ + + 0 Olanzapine +4.1 kg +++ ++ + + + + ++ ++ ++ ++ + Clozapine +4.5 kg +++ + + 0 + ++ ++ ++ + +++ +++ 
Legend- + / ++ / +++: Mild / Moderate / Severe side effect
- 0 / 0+: None to minimal effect or unclear data
- QTc↑: Prolonged QT interval (cardiac risk)
- Prolactin↑: Hormonal elevation (can affect libido, menstruation)
- Orthostatic Dysregulation: Drop in blood pressure when standing
- Constipation: Often due to anticholinergic effects
- Salivation: Excessive drooling, especially with Clozapine
- Weight Gain¹: Median over ~6 weeks (Pillinger et al., 2019)
Side Effect Matrix of Atypical Antipsychotics (Rotated Format)Side Effect Lurasidone Brexpiprazole Cariprazine Ziprasidone Aripiprazole Amisulpride Paliperidone Risperidone Quetiapine Olanzapine Clozapine Weight Gain (6 wks) +0.3 kg +0.6 kg +0.4 kg +0.5 kg +0.75 kg +2.5 kg +1.8 kg +2.1 kg +2.9 kg +4.1 kg +4.5 kg Sedation + + + + + ++ ++ ++ ++ +++ +++ Prolactin Elevation + + 0/+ 0/+ 0 +++ +++ +++ + ++ + QTc Prolongation + + + ++ + + ++ ++ + + + Akathisia ++ + ++ ++ ++ + ++ ++ + + 0 Parkinsonism + + + + + ++ + ++ + + + Tardive Dyskinesia + + + + 0 ++ + ++ + + ++ Diabetes Risk 0 0/+ 0 0 0 + + + + ++ ++ Orthostatic Dysreg. + + + + 0/+ + + + ++ ++ ++ Hypertension 0/+ 0/+ 0/+ 0 0/+ + ++ ++ 0/+ + + Constipation 0/+ 0/+ 0/+ 0/+ 0/+ + + + + ++ +++ Salivation 0 0 0 0 0 + + + 0 + +++ Legend- + / ++ / +++: Mild / Moderate / Severe side effect
- 0 / 0+: None to minimal effect or unclear data
- Weight Gain: Median over ~6 weeks (Pillinger et al., 2019)
- QTc↑: Prolonged QT interval (cardiac risk)
- Prolactin↑: Hormonal elevation (e.g. libido, menstruation)
- Orthostatic Dysregulation: Drop in blood pressure when standing
- Salivation: Excessive drooling, especially with Clozapine
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Laden…