Side Effects of Antipsychotics


Note: The following information is based on the S3 Guidelines for Schizophrenia, the study by Pillinger et al. (2019), and other expert sources. Please note that individual reactions to medications may vary and data may differ slightly depending on the study.

Explanations of Side Effects:

• (x): Minor side effect with unclear data.
• 0/x: No to minor side effect with unclear data.
• 0: No side effect.
• +, ++, +++: Increase in side effect intensity from minor to significant.
• Weight Gain: Average weight gain in kilograms over 12 weeks.

Note on Sources:

• The ratings are based on the S3 Guidelines for Schizophrenia, the study by Pillinger et al. (2019), and the overview by Leucht et al.
• The notation (x) is used when the data is uncertain or studies show conflicting results.
• Akathisia: Feeling of inner restlessness and urge to move.
• Parkinsonism: Symptoms such as tremors, muscle stiffness, and slow movements.
• Tardive Dyskinesia: Slow or uncontrolled movements, especially in the face and limbs, due to long-term use of antipsychotics.
• Weight Gain: Average weight gain in kilograms.
• Diabetes Mellitus: Increased risk of developing diabetes.
• QTc Interval Prolongation: Prolonged QT interval on ECG, increasing the risk of heart rhythm disorders.
• Orthostatic Hypotension: Drop in blood pressure upon standing, leading to dizziness or fainting.
• Hypertension: Chronically elevated blood pressure, which can increase the risk of cardiovascular diseases.
• Prolactin Increase: Elevated prolactin levels, which can lead to menstrual disorders, milk flow, and sexual dysfunction.
• Sexual Dysfunction: Impairment of sexual function, which can include loss of libido or erectile dysfunction.
• Menstrual Disorders: Irregularities in the menstrual cycle caused by hormonal changes.
• Sedation: Fatigue or drowsiness that can affect daily activity.
• Constipation: Difficulty or incomplete bowel movements.