Side Effect Matrix: Classic vs. Innovative Antipsychotics (12–24 Months)

[Maggi]

Side Effect Matrix: Classic vs. Innovative Antipsychotics (12–24 Months)

Categories Compared:

• Sedation
• Weight gain
• Extrapyramidal symptoms (EPS)
• Cognitive impairment
• Sexual dysfunction
• Prolactin increase
• Emotional flattening

Medications Included:

• Classic: Haloperidol, Risperidone, Paliperidone, Olanzapine
• Innovative: Lurasidone, Brexpiprazole

Key Insights:

• Classic antipsychotics show high incidence of sedation, EPS, and prolactin-related effects
• Innovative agents like Lurasidone and Brexpiprazole demonstrate significantly better tolerability across all categories
• Brexpiprazole’s D4 activity offers promise in treatment-resistant cases with fewer side effects